I feel like finding a good instance in the fediverse (that’s accepting users) is always a nightmare.
That being said, I’ve been happy with the vibes on lemmy.blahaj.zone and they have a calckey/firefish instance (that’s the main blahaj.zone). But it’s not strictly general-purpose.
The question is, if there are instances that are full of transphobic content, and they’re reported, does firefish defederate them. If they do, the view will improve. Although, global feeds are never very useful.